Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15
Summary: The age-related effects of GDF11 have been a subject of controversy. Here, we find that elevated GDF11 causes signs of cachexia in mice: reduced food intake, body weight, and muscle mass. GDF11 also elicited a significant elevation in plasma Activin A, previously shown to contribute to the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-02-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718300767 |
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by Juli E. Jones, Samuel M. Cadena, Chenguang Gong, Xiaomei Wang, Zhiping Chen, Sharon X. Wang, Chad Vickers, Hong Chen, Estelle Lach-Trifilieff, John R. Hadcock, David J. Glass
Published 2018-03-01
Get full textPublished 2018-03-01
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