Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps

Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps

Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), which mainly causes pulmonary injury and tubercles. Although macrophages are generally considered to harbor the main cells of M. tuberculosis, new evidence suggests that neutrophils are rapidly recruited to the infected lung. M....

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Bibliographic Details
Main Authors: Guanghui Dang, Yingying Cui, Lei Wang, Tiantian Li, Ziyin Cui, Ningning Song, Liping Chen, Hai Pang, Siguo Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
sphingomyelinase
Rv0888
neutrophil extracellular traps
lung injury
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00677/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00677/full

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