In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions

In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions

This study evaluated the effects of Newbouldia laevis and Cassia abbreviata extracts on CYP450 enzyme activity. Recombinant CYP450 enzyme and fluorogenic substrates were used for evaluating inhibition, allowing the assessment of herb–drug interactions (HDI). Phytochemical fingerprinting was performe...

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Bibliographic Details
Main Authors: Nicholas Ekow Thomford, Kevin Dzobo, Denis Chopera, Ambroise Wonkam, Alfred Maroyi, Dee Blackhurst, Collet Dandara
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Molecules
Subjects:
time-dependent inhibition (TDI)
CYP450
IC50
Newbouldia laevis
Cassia abbreviata
rCYP
Online Access:http://www.mdpi.com/1420-3049/21/7/891

Internet

http://www.mdpi.com/1420-3049/21/7/891

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