Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells

Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells

Abstract Background Nicotinamide N-methyltransferase (NNMT) is highly expressed in several cancers and can regulate cell epigenetic status and various cell metabolism pathways, such as ATP synthesis and cellular stress response. We reported in our previous papers that NNMT overexpression inhibits th...

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Bibliographic Details
Main Authors: Haitao Yu, Xi Zhou, Yanzhong Wang, Xucheng Huang, Jun Yang, Jin Zeng, Guoli Li, Xinyou Xie, Jun Zhang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Cancer Cell International
Subjects:
Nicotinamide N-methyltransferase
Autophagy
Oxidative stress
AMPK
ULK1
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s12935-020-01279-8

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http://link.springer.com/article/10.1186/s12935-020-01279-8

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