Simvastatin assay and dissolution studies by feasible RP-HPLC in tablets

Commonly used HPLC acetonitrile solvent has been through a worldwide shortage with a cost increase in 2008 and 2009. In order to get around this situation, a method by RP-HPLC employing methanol and aqueous acid mobile phase was developed and validated to evaluate simvastatin. The quality control as...

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Bibliographic Details
Main Authors: Flávia Dias Marques-Marinho, Amanda Leão dos Santos, Cristina Duarte Vianna-Soares, Ilka Afonso Reis, José Carlos da Costa Zanon, Angélica Alves Lima
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2012-01-01
Series:Química Nova
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600031&lng=en&tlng=en