AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions

AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions

Abstract Background mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. Results As a proof of principle, we show in both cell...

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Bibliographic Details
Main Authors: Nathalie Bouquier, Enora Moutin, Lionel A. Tintignac, Amandine Reverbel, Elodie Jublanc, Michael Sinnreich, Yan Chastagnier, Julien Averous, Pierre Fafournoux, Chiara Verpelli, Tobias Boeckers, Gilles Carnac, Julie Perroy, Vincent Ollendorff
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Biology
Subjects:
mTor signaling
mTORC1 Biosensor
BRET
Muscle differentiation
mToropathies
Neuronal activity
Online Access:http://link.springer.com/article/10.1186/s12915-020-00790-8

Internet

http://link.springer.com/article/10.1186/s12915-020-00790-8

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