Immunization With a Secreted Esterase Protects Mice Against Multiple Serotypes (M1, M3, and M28) of Group A Streptococcus

Immunization With a Secreted Esterase Protects Mice Against Multiple Serotypes (M1, M3, and M28) of Group A Streptococcus

Streptococcal secreted esterase (Sse) is a platelet-activating factor acetylhydrolase that is critical for Group A Streptococcus (GAS) skin invasion and innate immune evasion. There are two Sse variant complexes that share >98% identity within each complex but display about 37% variation betw...

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Bibliographic Details
Main Authors: Xiaolan Zhang, Deqin Wei, Yuan Zhao, Zhaohua Zhong, Yue Wang, Yingli Song, Minghui Cai, Wenli Zhang, Jizi Zhao, Chunmei Lv, Hui Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Microbiology
Subjects:
group A streptococcus (GAS)
protective effect
streptococcal secreted esterase (Sse)
immunization
mice
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00565/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00565/full

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