Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles

Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles

2-Amino-5-(2-aryl-2H-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles 2-4 have been synthesized by the reaction of 2-aryl-2H-1,2,3-triazole-4-carboxylic acids 1 with thiosemicarbazide. Their reaction with phenacyl (p-substituted phenacyl) bromides led to formation of the respective 6-aryl-2-(2-aryl-2H-1,2,3-t...

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Bibliographic Details
Main Authors: Kamal F. M. Atta, Omaima O.M. Farahat, Mohamed G. Marei, Alaa Z. A. Ahmed
Format: Article
Language:English
Published: MDPI AG 2011-06-01
Series:Molecules
Subjects:
1,3,4-thiadiazole
imidazo[2,1-b]thiadiazole
electrophile
thiosemicarbazide
phenacyl bromide
antimicrobial activity
Online Access:http://www.mdpi.com/1420-3049/16/7/5496/

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http://www.mdpi.com/1420-3049/16/7/5496/

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