Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts

Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts

Amiodarone is a potent antidysrhythmic agent that can cause potentially life-threatening pulmonary fibrosis. Accumulating evidence has demonstrated that myofibroblast differentiation is related to the pathogenesis of pulmonary fibrosis. In the present study, we treated human embryonic lung fibroblas...

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Bibliographic Details
Main Authors: Jie Weng, Mengyun Tu, Peng Wang, Xiaoming Zhou, Chuanyi Wang, Xinlong Wan, Zhiliang Zhou, Liang Wang, Xiaoqun Zheng, Junjian Li, Zhibin Wang, Zhiyi Wang, Chan Chen
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Amiodarone
ERK1/2
p38 MAPK
Myofibroblast differentiation
Pulmonary fibrosis
HELFs
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218378752

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http://www.sciencedirect.com/science/article/pii/S0753332218378752

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