SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression

SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression

Enhancers shape gene expression patterns and are involved in disease pathogenesis. Here the authors demonstrate a strategy to screen functional regulatory elements for non-coding RNAs ― illustrated with miR-146a ― and link autoimmune disease risk genetic variants to autoimmune disease etiology.

Bibliographic Details
Main Authors: Guojun Hou, Isaac T. W. Harley, Xiaoming Lu, Tian Zhou, Ning Xu, Chao Yao, Yuting Qin, Ye Ouyang, Jianyang Ma, Xinyi Zhu, Xiang Yu, Hong Xu, Dai Dai, Huihua Ding, Zhihua Yin, Zhizhong Ye, Jun Deng, Mi Zhou, Yuanjia Tang, Bahram Namjou, Ya Guo, Matthew T. Weirauch, Leah C. Kottyan, John B. Harley, Nan Shen
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20460-1

Internet

https://doi.org/10.1038/s41467-020-20460-1

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