Accuracy of Programs for the Determination of Human Leukocyte Antigen Alleles from Next-Generation Sequencing Data

Accuracy of Programs for the Determination of Human Leukocyte Antigen Alleles from Next-Generation Sequencing Data

The human leukocyte antigen (HLA) genes code for proteins that play a central role in the function of the immune system by presenting peptide antigens to T cells. As HLA genes show extremely high genetic polymorphism, HLA typing at the allele level is demanding and is based on DNA sequencing. Determ...

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Bibliographic Details
Main Authors: Antti Larjo, Robert Eveleigh, Elina Kilpeläinen, Tony Kwan, Tomi Pastinen, Satu Koskela, Jukka Partanen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
genetic variation
histocompatibility
human leukocyte antigen alleles
genome sequence
transplantation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01815/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01815/full

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