Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research

Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research

The human small intestine is the key organ for absorption, metabolism, and excretion of orally administered drugs. To preclinically predict these reactions in drug discovery research, a cell model that can precisely recapitulate the in vivo human intestinal monolayer is desired. In this study, we de...

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Bibliographic Details
Main Authors: Tomoki Yamashita, Tatsuya Inui, Jumpei Yokota, Kentaro Kawakami, Gaku Morinaga, Masahito Takatani, Daisuke Hirayama, Ryuga Nomoto, Kohei Ito, Yunhai Cui, Stephanie Ruez, Kazuo Harada, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
intestinal organoids
small intestine
intestinal first-pass effect
monolayer culture
CYP3A4
P-glycoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000899

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http://www.sciencedirect.com/science/article/pii/S2329050121000899

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