Halogenation of the N‐Terminus Tyrosine 10 Promotes Supramolecular Stabilization of the Amyloid‐β Sequence 7–12

Halogenation of the N‐Terminus Tyrosine 10 Promotes Supramolecular Stabilization of the Amyloid‐β Sequence 7–12

Abstract Here, we demonstrate that introduction of halogen atoms at the tyrosine 10 phenol ring of the DSGYEV sequence derived from the flexible amyloid‐β N‐terminus, promotes its self‐assembly in the solid state. In particular, we report the crystal structures of two halogen‐modified sequences, whi...

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Bibliographic Details
Main Authors: Dr. Daniele Maiolo, Dr. Andrea Pizzi, Dr. Alessandro Gori, Dr. Lara Gazzera, Dr. Nicola Demitri, Dr. Alessandro Genoni, Dr. Fulvio Baggi, Dr. Fabio Moda, Prof. Dr. Giancarlo Terraneo, Prof. Dr. Francesca Baldelli Bombelli, Prof. Dr. Pierangelo Metrangolo, Prof. Dr. Giuseppe Resnati
Format: Article
Language:English
Published: Wiley-VCH 2020-02-01
Series:ChemistryOpen
Subjects:
halogen bonding
crystal engineering
supramolecular
bromine
peptide
Online Access:https://doi.org/10.1002/open.201900350

Internet

https://doi.org/10.1002/open.201900350

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