Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma: Increased Cell Migration and Its Association with EGFR Expression

Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma: Increased Cell Migration and Its Association with EGFR Expression

Acquired resistance during BRAF inhibitor therapy remains a major challenge for melanoma treatment. Accordingly, we evaluated the phenotypical and molecular changes of isogeneic human V600E BRAF-mutant melanoma cell line pairs pre- and post-treatment with vemurafenib. Three treatment naïve...

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Bibliographic Details
Main Authors: Eszter Molnár, Tamás Garay, Marco Donia, Marcell Baranyi, Dominika Rittler, Walter Berger, József Tímár, Michael Grusch, Balázs Hegedűs
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
melanoma
V600E BRAF mutation
vemurafenib resistance
EGFR
PD-L1
migration
Online Access:https://www.mdpi.com/1422-0067/20/18/4484

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https://www.mdpi.com/1422-0067/20/18/4484

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