Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy

Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy

Over the last decades, beta-blockers have been a key component of heart failure therapy. However, currently there is no method to identify patients who will benefit from beta-blocking therapy versus those who will be unresponsive or worsen. Furthermore, there is an unmet need to better understand mo...

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Bibliographic Details
Main Authors: Bettina Heidecker, MD, Michelle M. Kittleson, MD, PhD, Edward K. Kasper, MD, Ilan S. Wittstein, MD, Hunter C. Champion, MD, PhD, Stuart D. Russell, MD, Kenneth L. Baughman, MD, Joshua M. Hare, MD
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:JACC: Basic to Translational Science
Subjects:
beta-blocking agents
biomarker
gene expression
heart failure
transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16000358

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http://www.sciencedirect.com/science/article/pii/S2452302X16000358

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