Specific epigenetic microenvironment and the regulation of tumor-related gene expression by trichloroethylene in human hepatocytes

Specific epigenetic microenvironment and the regulation of tumor-related gene expression by trichloroethylene in human hepatocytes

Trichloroethylene (TCE), an important volatile organic solvent, causes a series of toxic damage to human. Conventional genetic mechanisms cannot fully explain its toxicity and carcinogenicity, indicative of the possible involvement of epigenetic mechanisms. Our study was intended to investigate the...

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Bibliographic Details
Main Authors: Caiyun Lai, Fan Wu, Yan Wang, Wei Wang, Yueqi Li, Gaoqiang Zhang, Jianji Gao, Zhiliang Zhu, Jianhui Yuan, Jianping Yang, Wenjuan Zhang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Trichloroethylene
N-Ras
C-jun
C-Myc
C-Fos
IGF-II
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651320312902

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http://www.sciencedirect.com/science/article/pii/S0147651320312902

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