Maternal SNPs in the p53 Pathway: Risk Factors for Trisomy 21?

The p53 family and its regulatory pathway play an important role as regulators of developmental processes, limiting the propagation of aneuploid cells. Its dysfunction or imbalance can lead to pathological abnormalities in humans. The aim of this study was to evaluate the effect of maternal polymorp...

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Bibliographic Details
Main Authors: Juliano André Boquett, Ana Paula Carneiro Brandalize, Lucas Rosa Fraga, Lavínia Schuler-Faccini
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.3233/DMA-2012-00937