Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model

Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model

Abstract Background Porphyromonas gingivalis (Pg) infection causes periodontal disease and exacerbates rheumatoid arthritis (RA). It is reported that inoculation of periodontopathogenic bacteria (i.e., Pg) can alter gut microbiota composition in the animal models. Gut microbiota dysbiosis in human h...

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Main Authors: Yuta Hamamoto, Kazuhisa Ouhara, Syuichi Munenaga, Mikio Shoji, Tatsuhiko Ozawa, Jyunzo Hisatsune, Isamu Kado, Mikihito Kajiya, Shinji Matsuda, Toshihisa Kawai, Noriyoshi Mizuno, Tsuyoshi Fujita, Shintaro Hirata, Kotaro Tanimoto, Koji Nakayama, Hiroyuki Kishi, Eiji Sugiyama, Hidemi Kurihara
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Arthritis Research & Therapy
Subjects:
Porphyromonas gingivalis
Rheumatoid arthritis
Periodontitis
Citrullinated protein
Dysbiosis
Online Access:http://link.springer.com/article/10.1186/s13075-020-02348-z

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