Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity

Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity

Twenty-five piperidines were studied as potential radical scavengers and antitumor agents. Quantitative interaction of compounds with ctDNA using spectroscopic techniques was also evaluated. Our results demonstrate that the evaluated piperidines possesses different abilities to scavenge the radical...

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Bibliographic Details
Main Authors: Suvankar Das, Cristiane J. da Silva, Marina de M. Silva, Maria Dayanne de A. Dantas, Ângelo de Fátima, Ana Lúcia T. Góis Ruiz, Cleiton M. da Silva, João Ernesto de Carvalho, Josué C.C. Santos, Isis M. Figueiredo, Edeildo F. da Silva-Júnior, Thiago M. de Aquino, João X. de Araújo-Júnior, Goutam Brahmachari, Luzia Valentina Modolo
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Advanced Research
Subjects:
Piperidine derivatives
Free radical scavenging
Anticancer activity
DNA interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123217301145

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http://www.sciencedirect.com/science/article/pii/S2090123217301145

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