A mechanism for exocytotic arrest by the Complexin C-terminus

A mechanism for exocytotic arrest by the Complexin C-terminus

ComplexinII (CpxII) inhibits non-synchronized vesicle fusion, but the underlying mechanisms have remained unclear. Here, we provide evidence that the far C-terminal domain (CTD) of CpxII interferes with SNARE assembly, thereby arresting tonic exocytosis. Acute infusion of a CTD-derived peptide into...

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Bibliographic Details
Main Authors: Mazen Makke, Maria Mantero Martinez, Surya Gaya, Yvonne Schwarz, Walentina Frisch, Lina Silva-Bermudez, Martin Jung, Ralf Mohrmann, Madhurima Dhara, Dieter Bruns
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
vesicle fusion
neurotransmitter release
exocytotic arrest
complexin
SNAREs
Online Access:https://elifesciences.org/articles/38981

Internet

https://elifesciences.org/articles/38981

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