Histidine deficiency attenuates cell viability in rat intestinal epithelial cells by apoptosis via mitochondrial dysfunction

Histidine deficiency attenuates cell viability in rat intestinal epithelial cells by apoptosis via mitochondrial dysfunction

Objective: To reveal the importance of histidine in intestinal epithelial cells, we investigated whether reduction in histidine concentration affects cell viability and apoptosis in rat intestinal epithelial cells (IEC-6). Methods: Culture cells were incubated in DMEM with or without histidine. Cell...

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Bibliographic Details
Main Authors: Tatsunobu Matsui, M.S., Hiroshi Ichikawa, M.D., Ph.D., Tomoka Fujita, M.S., Tomohisa Takagi, M.D., Ph.D., Mayuko Osada-Oka, Ph.D., Yukiko Minamiyama, Ph.D.
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Journal of Nutrition & Intermediary Metabolism
Subjects:
Histidine deficiency
Intestinal epithelial cell
Cell viability
Apoptosis
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2352385916300330

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http://www.sciencedirect.com/science/article/pii/S2352385916300330

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