Downregulation of POFUT1 Impairs Secondary Myogenic Fusion Through a Reduced NFATc2/IL-4 Signaling Pathway

Downregulation of POFUT1 Impairs Secondary Myogenic Fusion Through a Reduced NFATc2/IL-4 Signaling Pathway

Past work has shown that the protein <i>O</i>-fucosyltransferase 1 (POFUT1) is involved in mammal myogenic differentiation program. <i>Pofut1</i> knockdown (Po &#8722;) in murine C2C12 cells leads to numerous elongated and thin myotubes, suggesting significant defects in...

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Bibliographic Details
Main Authors: Audrey Der Vartanian, Julien Chabanais, Claire Carrion, Abderrahman Maftah, Agnès Germot
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
IL-4
myogenic differentiation
NFATc2
NOTCH pathway
POFUT1
secondary fusion
Online Access:https://www.mdpi.com/1422-0067/20/18/4396

Internet

https://www.mdpi.com/1422-0067/20/18/4396

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