Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer

Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer

Summary: The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer progression remain to be fully understood. While altered glucose metabolism in CAFs could fuel cancer cells, how such metabolic reprogramming emerges and is sustained needs further investigation. Studying...

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Bibliographic Details
Main Authors: Lisa M. Becker, Joyce T. O’Connell, Annie P. Vo, Margo P. Cain, Desiree Tampe, Lauren Bizarro, Hikaru Sugimoto, Anna K. McGow, John M. Asara, Sara Lovisa, Kathleen M. McAndrews, Rafal Zielinski, Philip L. Lorenzi, Michael Zeisberg, Sughra Raza, Valerie S. LeBleu, Raghu Kalluri
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
breast cancer
cancer-associated fibroblasts
metabolism
hypoxia
epigenetic alterations
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306719

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http://www.sciencedirect.com/science/article/pii/S2211124720306719

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