Serum response factor accelerates the high glucose-induced Epithelial-to-Mesenchymal Transition (EMT) via snail signaling in human peritoneal mesothelial cells.

Serum response factor accelerates the high glucose-induced Epithelial-to-Mesenchymal Transition (EMT) via snail signaling in human peritoneal mesothelial cells.

BACKGROUND: Epithelial-to-Mesenchymal Transition (EMT) induced by glucose in human peritoneal mesothelial cells (HPMCs) is a major cause of peritoneal membrane (PM) fibrosis and dysfunction. METHODS: To investigate serum response factor (SRF) impacts on EMT-derived fibrosis in PM, we isolated HPMCs...

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Bibliographic Details
Main Authors: Lijie He, Weijuan Lou, Lihua Ji, Wei Liang, Meilan Zhou, Guoshang Xu, Lijuan Zhao, Chen Huang, Rong Li, Hanmin Wang, Xiangmei Chen, Shiren Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4193747?pdf=render

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http://europepmc.org/articles/PMC4193747?pdf=render

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