Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade

Phenotypic switch of vascular smooth muscle cells (VSMCs) is characterized by increased expressions of VSMC synthetic markers and decreased levels of VSMC contractile markers, which is an important step for VSMC proliferation and migration during the development and progression of cardiovascular dis...

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Bibliographic Details
Main Authors: Qing-Bo Lu, Ming-Yu Wan, Pei-Yao Wang, Chen-Xing Zhang, Dong-Yan Xu, Xiang Liao, Hai-Jian Sun
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S221323171730808X