DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936

Abstract Background The biological mechanisms underlying frailty in older people are poorly understood. There is some evidence to suggest that DNA methylation patterns may be altered in frail individuals. Methods Participants were 791 people aged 70 years from the Lothian Birth Cohort 1936. DNA meth...

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Bibliographic Details
Main Authors: Catharine R. Gale, Riccardo E. Marioni, Sarah E. Harris, John M. Starr, Ian J. Deary
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Clinical Epigenetics
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13148-018-0538-4