PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions.

PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions.

Atherosclerosis is an inflammatory disease regulated by infiltrating monocytes and T cells, among other cell types. Macrophage recruitment to atherosclerotic lesions is controlled by monocyte infiltration into plaques. Once in the lesion, macrophage proliferation in situ, apoptosis, and differentiat...

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Bibliographic Details
Main Authors: Teresa M Zotes, Cristina F Arias, José J Fuster, Roberto Spada, Sonia Pérez-Yagüe, Emilio Hirsch, Matthias Wymann, Ana C Carrera, Vicente Andrés, Domingo F Barber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23991137/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23991137/?tool=EBI

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