PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions.
Atherosclerosis is an inflammatory disease regulated by infiltrating monocytes and T cells, among other cell types. Macrophage recruitment to atherosclerotic lesions is controlled by monocyte infiltration into plaques. Once in the lesion, macrophage proliferation in situ, apoptosis, and differentiat...
Main Authors: | Teresa M Zotes, Cristina F Arias, José J Fuster, Roberto Spada, Sonia Pérez-Yagüe, Emilio Hirsch, Matthias Wymann, Ana C Carrera, Vicente Andrés, Domingo F Barber |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23991137/?tool=EBI |
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