The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers.

The primary constituents of plaques (Aβ42/Aβ40) and neurofibrillary tangles (tau and phosphorylated forms of tau [ptau]) are the current leading diagnostic and prognostic cerebrospinal fluid (CSF) biomarkers for AD. In this study, we performed deep sequencing of APP, PSEN1, PSEN2, GRN, APOE and MAPT...

Full description

Bibliographic Details
Main Authors: Bruno A Benitez, Celeste M Karch, Yefei Cai, Sheng Chih Jin, Breanna Cooper, David Carrell, Sarah Bertelsen, Lori Chibnik, Julie A Schneider, David A Bennett, Alzheimer's Disease Neuroimaging Initiative, Genetic and Environmental Risk for Alzheimer's Disease Consortium GERAD, Anne M Fagan, David Holtzman, John C Morris, Alison M Goate, Carlos Cruchaga
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3750021?pdf=render

Similar Items