Integration of Microfractionation, qNMR and zebrafish screening for the in vivo bioassay-guided isolation and quantitative bioactivity analysis of natural products.

Integration of Microfractionation, qNMR and zebrafish screening for the in vivo bioassay-guided isolation and quantitative bioactivity analysis of natural products.

Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovery. Several challenges nevertheless persist with respect to NP discovery, including the time and effort required for bioassay-guided isolation of bioactive NPs, and the limited biomedical relevance t...

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Bibliographic Details
Main Authors: Nadine Bohni, María Lorena Cordero-Maldonado, Jan Maes, Dany Siverio-Mota, Laurence Marcourt, Sebastian Munck, Appolinary R Kamuhabwa, Mainen J Moshi, Camila V Esguerra, Peter A M de Witte, Alexander D Crawford, Jean-Luc Wolfender
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23700445/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23700445/pdf/?tool=EBI

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