An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases
Malate and lactate dehydrogenases (MDH and LDH) are homologous, core metabolic enzymes that share a fold and catalytic mechanism yet possess strict specificity for their substrates. In the Apicomplexa, convergent evolution of an unusual LDH from MDH produced a difference in specificity exceeding 12...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-06-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/02304 |