Trophectoderm-Specific Knockdown of LIN28 Decreases Expression of Genes Necessary for Cell Proliferation and Reduces Elongation of Sheep Conceptus

Trophectoderm-Specific Knockdown of LIN28 Decreases Expression of Genes Necessary for Cell Proliferation and Reduces Elongation of Sheep Conceptus

LIN28 inhibits <i>let-7 </i>miRNA maturation which prevents cell differentiation and promotes proliferation. We hypothesized that the LIN28-<i>let-7 </i>axis regulates proliferation-associated genes in sheep trophectoderm in vivo. Day 9-hatched sheep blastocysts were incubate...

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Bibliographic Details
Main Authors: Asghar Ali, Mark D. Stenglein, Thomas E. Spencer, Gerrit J. Bouma, Russell V. Anthony, Quinton A. Winger
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
trophectoderm
placenta
cell proliferation
<i>let-7</i> miRNAs
gene regulation
Online Access:https://www.mdpi.com/1422-0067/21/7/2549

Internet

https://www.mdpi.com/1422-0067/21/7/2549

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