The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S

The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S

Cyclic β-sheet decapeptides, such as tyrocidines and gramicidin S, were among the first antibiotics in clinical application. Although they have been used for such a long time, there is virtually no resistance to them, which has led to a renewed interest in this peptide class. Both tyrocidines and gr...

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Bibliographic Details
Main Authors: Michaela Wenzel, Marina Rautenbach, J. Arnold Vosloo, Tjalling Siersma, Christopher H. M. Aisenbrey, Ekaterina Zaitseva, Wikus E. Laubscher, Wilma van Rensburg, Jan C. Behrends, Burkhard Bechinger, Leendert W. Hamoen
Format: Article
Language:English
Published: American Society for Microbiology 2018-10-01
Series:mBio
Subjects:
antibiotics
antimicrobial peptides
bacterial cell biology
bacterial cytological profiling
cell membranes
mode of action
Online Access:https://doi.org/10.1128/mBio.00802-18

Internet

https://doi.org/10.1128/mBio.00802-18

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