Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMNResearch in context

Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMNResearch in context

Background: Exposure to anesthetics during early life may impair cognitive functions. However, the underlying mechanisms remain largely unknown. We set out to determine effects of sevoflurane anesthesia on folate metabolism and myelination in young non-human primates, mice and children. Methods: You...

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Bibliographic Details
Main Authors: Lei Zhang, Zhenyu Xue, Qidong Liu, Yunbo Liu, Siwei Xi, Yanyong Cheng, Jingjie Li, Jia Yan, Yuan Shen, Chong Xiao, Zhongcong Xie, Zilong Qiu, Hong Jiang
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419302877

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http://www.sciencedirect.com/science/article/pii/S2352396419302877

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