Cell fate potentials and switching kinetics uncovered in a classic bistable genetic switch

Bistable switches are a common regulatory motif in cell fate decision-making circuits with two mutually exclusive expression states. Here the authors develop a bistable reporter system and report two additional expression states.

Bibliographic Details
Main Authors: Xiaona Fang, Qiong Liu, Christopher Bohrer, Zach Hensel, Wei Han, Jin Wang, Jie Xiao
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05071-1