Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains

Abstract Cell motility and migration requires the reorganization of the cortical cytoskeleton at the leading edge of cells and extracellular Ca2+ entry is essential for this reorganization. However the molecular nature of the regulators of this pathway is unknown. This work contributes to understand...

Full description

Bibliographic Details
Main Authors: Aida M. Lopez-Guerrero, Patricia Tomas-Martin, Carlos Pascual-Caro, Thomas Macartney, Alejandro Rojas-Fernandez, Graeme Ball, Dario R. Alessi, Eulalia Pozo-Guisado, Francisco Javier Martin-Romero
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-00331-4