The five-to-six-coordination transition of ferric human serum heme-albumin is allosterically-modulated by ibuprofen and warfarin: a combined XAS and MD study.

The five-to-six-coordination transition of ferric human serum heme-albumin is allosterically-modulated by ibuprofen and warfarin: a combined XAS and MD study.

Human serum albumin (HSA) is involved physiologically in heme scavenging; in turn, heme-albumin (HSA-heme-Fe) displays globin-like properties. Here, the allosteric effect of ibuprofen and warfarin on the local atomic structure around the ferric heme-Fe (heme-Fe(III)) atom of HSA-heme-Fe (HSA-heme-Fe...

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Bibliographic Details
Main Authors: Carlo Meneghini, Loris Leboffe, Monica Bionducci, Gabriella Fanali, Massimiliano Meli, Giorgio Colombo, Mauro Fasano, Paolo Ascenzi, Settimio Mobilio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25153171/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25153171/?tool=EBI

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