OptMAVEn-2.0: De novo Design of Variable Antibody Regions Against Targeted Antigen Epitopes

OptMAVEn-2.0: De novo Design of Variable Antibody Regions Against Targeted Antigen Epitopes

Monoclonal antibodies are becoming increasingly important therapeutic agents for the treatment of cancers, infectious diseases, and autoimmune disorders. However, laboratory-based methods of developing therapeutic monoclonal antibodies (e.g., immunized mice, hybridomas, and phage display) are time-c...

Full description

Bibliographic Details
Main Authors:	Ratul Chowdhury, Matthew F. Allan, Costas D. Maranas
Format:	Article
Language:	English
Published:	MDPI AG 2018-06-01
Series:	Antibodies
Subjects:	de novo antibody design zika envelope protein computational protein design specific antigen epitope
Online Access:	http://www.mdpi.com/2073-4468/7/3/23

Similar Items

OptMAVEn-2.0: De novo Design of Variable Antibody Regions Against Targeted Antigen Epitopes
by: Chowdhury, Ratul, et al.
Published: (2018)

OptMAVEn--a new framework for the de novo design of antibody variable region models targeting specific antigen epitopes.
by: Tong Li, et al.
Published: (2014-01-01)

Concerns with computational protein engineering programmes IPRO and OptMAVEn and metabolic pathway engineering programme optStoic
by: Thomas K. Wood
Published: (2021-02-01)

Computationally-driven identification of antibody epitopes
by: Casey K Hua, et al.
Published: (2017-12-01)

Characterizing Epitope Binding Regions of Entire Antibody Panels by Combining Experimental and Computational Analysis of Antibody: Antigen Binding Competition
by: Benjamin D. Brooks, et al.
Published: (2020-08-01)

ZIKV Envelope Domain-Specific Antibodies: Production, Purification and Characterization
by: Sami Akhras, et al.
Published: (2019-08-01)

Characterization and epitope mapping of Dengue virus type 1 specific monoclonal antibodies
by: Wen-Hung Chen, et al.
Published: (2017-10-01)

Benchmarking the PEPOP methods for mimicking discontinuous epitopes
by: Vincent Demolombe, et al.
Published: (2019-12-01)

Screening and identification of B-cell epitopes within envelope protein of tembusu virus
by: Dongmin Zhao, et al.
Published: (2018-09-01)

The Possible Effect of B-Cell Epitopes of Epstein–Barr Virus Early Antigen, Membrane Antigen, Latent Membrane Protein-1, and -2A on Systemic Lupus Erythematosus
by: Jianxin Tu, et al.
Published: (2018-02-01)

An Approach for a Synthetic CTL Vaccine Design against Zika Flavivirus Using Class I and Class II Epitopes Identified by Computer Modeling
by: Edecio Cunha-Neto, et al.
Published: (2017-06-01)

Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes
by: Minchao Li, et al.
Published: (2021-02-01)

Characterization of Antigenic Properties and High Throughput Protein Purification
by: Steen, Johanna
Published: (2010)

Selection of antigens for antibody-based proteomics
by: Berglund, Lisa
Published: (2008)

Generation of Monoclonal Antibodies against Variable Epitopes of the M Protein of Rabies Virus
by: Jie Liu, et al.
Published: (2019-04-01)

Measles Virus Hemagglutinin Protein Epitopes: The Basis of Antigenic Stability
by: Maino Tahara, et al.
Published: (2016-08-01)

In silico prediction of a highly immunogenic and conserved epitope against Zika Virus
by: Debasish Paul, et al.
Published: (2021-01-01)

Significance of Antigen and Epitope Specificity in Tuberculosis
by: Juraj eIvanyi, et al.
Published: (2014-10-01)

Characterization of novel Omp31 antigenic epitopes of Brucella melitensis by monoclonal antibodies
by: Jinfeng Li, et al.
Published: (2017-05-01)

Epitopes identified in GAPDH from Clostridium difficile recognized as common antigens with potential autoimmunizing properties
by: Agnieszka Razim, et al.
Published: (2018-09-01)

Recent Progress Using De Novo Design to Study Protein Structure, Design and Binding Interactions
by: Juan Ferrando, et al.
Published: (2021-03-01)

Antibody Specific B-Cell Epitope Predictions: Leveraging Information From Antibody-Antigen Protein Complexes
by: Martin Closter Jespersen, et al.
Published: (2019-02-01)

PEPOP 2.0: new approaches to mimic non-continuous epitopes
by: Vincent Demolombe, et al.
Published: (2019-07-01)

Epitope finding in Zika virus molecule: The first world report
by: Somsri Wiwanitkit, et al.
Published: (2017-01-01)

Epitope Mapping of Exposed Tegument and Alimentary Tract Proteins Identifies Putative Antigenic Targets of the Attenuated Schistosome Vaccine
by: Leonardo P. Farias, et al.
Published: (2021-03-01)

Complexity of Human Antibody Response to Dengue Virus: Implication for Vaccine Development
by: Wen-Yang Tsai, et al.
Published: (2017-07-01)

A docking-based method for in silico epitope determination
by: Tahir, Shifa
Published: (2018)

Identification of specific B cell linear epitopes of mycoplasma hyorhinis P37 protein using monoclonal antibodies against baculovirus-expressed P37 protein
by: Hongzhen Zhu, et al.
Published: (2019-11-01)

Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species
by: Jamie E. Fegan, et al.
Published: (2019-02-01)

Alanine Substitution Inactivates Cross-Reacting Epitopes in Dengue Virus Recombinant Envelope Proteins
by: Viviana C. Zomosa-Signoret, et al.
Published: (2020-02-01)

Identification of B-Cell Epitopes with Potential to Serologicaly Discrimnate Dengue from Zika Infections
by: Alice F. Versiani, et al.
Published: (2019-11-01)

Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection
by: Maximilian Koblischke, et al.
Published: (2018-05-01)

A Basic Molecular Analysis of the Diabetic Antigen GAD by Homology Modelling. Principles of the Method and Understanding of Antigenicity and Binding Sites
by: Wiltgen Marco, et al.
Published: (2007-02-01)

Corrigendum: Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection
by: Maximilian Koblischke, et al.
Published: (2018-09-01)

Toward a Database of Geometric Interrelationships of Protein Secondary Structure Elements for De Novo Protein Design, Prediction and Analysis
by: Orgah, Augustine Ada
Published: (2010)

Mutations in SARS-CoV-2 Leading to Antigenic Variations in Spike Protein: A Challenge in Vaccine Development
by: Praveen Kumar Singh, et al.
Published: (2020-08-01)

Spike protein-based epitopes predicted against SARS-CoV-2 through literature mining
by: Wendong Li, et al.
Published: (2020-12-01)

Humoral Epitope Spreading in Autoimmune Bullous Diseases
by: Dario Didona, et al.
Published: (2018-04-01)

De novo design of a homo-trimeric amantadine-binding protein
by: Jooyoung Park, et al.
Published: (2019-12-01)

Zika viral proteome analysis reveals an epitope cluster within NS3 helicase as a potential vaccine candidate: An in silico study
by: Md Tangigul Haque, et al.
Published: (2020-01-01)