Mechanisms of Lin28-Mediated miRNA and mRNA Regulation—A Structural and Functional Perspective

Mechanisms of Lin28-Mediated miRNA and mRNA Regulation—A Structural and Functional Perspective

Lin28 is an essential RNA-binding protein that is ubiquitously expressed in embryonic stem cells. Its physiological function has been linked to the regulation of differentiation, development, and oncogenesis as well as glucose metabolism. Lin28 mediates these pleiotropic functions by inhibiting let-...

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Bibliographic Details
Main Authors: Udo Heinemann, Florian Mayr
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:International Journal of Molecular Sciences
Subjects:
Lin28
let-7 miRNA
miRNA processing
RNA-binding protein
cold-shock domain
zinc-knuckle domain
TUTase
oncogene
stem cell
Online Access:http://www.mdpi.com/1422-0067/14/8/16532

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http://www.mdpi.com/1422-0067/14/8/16532

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