Super-resolution visualization and modeling of human chromosomal regions reveals cohesin-dependent loop structures

Super-resolution visualization and modeling of human chromosomal regions reveals cohesin-dependent loop structures

Abstract Background The 3D organization of the chromatin fiber in cell nuclei plays a key role in the regulation of gene expression. Genome-wide techniques to score DNA-DNA contacts, such as Hi-C, reveal the partitioning of chromosomes into epigenetically defined active and repressed compartments an...

Full description

Bibliographic Details
Main Authors: Xian Hao, Jyotsana J. Parmar, Benoît Lelandais, Andrey Aristov, Wei Ouyang, Christian Weber, Christophe Zimmer
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Genome Biology
Subjects:
Chromatin
Chromosomes
Cohesin
Super-resolution microscopy
Polymer models
Online Access:https://doi.org/10.1186/s13059-021-02343-w

Internet

https://doi.org/10.1186/s13059-021-02343-w

Similar Items