Super-resolution visualization and modeling of human chromosomal regions reveals cohesin-dependent loop structures
Abstract Background The 3D organization of the chromatin fiber in cell nuclei plays a key role in the regulation of gene expression. Genome-wide techniques to score DNA-DNA contacts, such as Hi-C, reveal the partitioning of chromosomes into epigenetically defined active and repressed compartments an...
Main Authors: | Xian Hao, Jyotsana J. Parmar, Benoît Lelandais, Andrey Aristov, Wei Ouyang, Christian Weber, Christophe Zimmer |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-05-01
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Series: | Genome Biology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13059-021-02343-w |
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