PDCD10-Deficiency Promotes Malignant Behaviors and Tumor Growth via Triggering EphB4 Kinase Activity in Glioblastoma

PDCD10-Deficiency Promotes Malignant Behaviors and Tumor Growth via Triggering EphB4 Kinase Activity in Glioblastoma

We previously reported an angiogenic and tumor-suppressor-like function of programmed cell death 10 (PDCD10) in glioblastoma (GBM). However, the underlying mechanism remains to be elucidated. We hypothesized that loss of PDCD10 activates GBM cells and tumor progression via EphB4. To this end, PDCD10...

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Bibliographic Details
Main Authors: Xueyan Wan, Dino Vitali Saban, Su Na Kim, Yinlun Weng, Philipp Dammann, Kathy Keyvani, Ulrich Sure, Yuan Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
EphB4 and EphB4 kinase inhibition
PDCD10/CCM3
lentivirus mediated shRNA transduction
glioblastoma
tumor malignant behavior
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01377/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01377/full

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