Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo

Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo

Abstract Background Tamoxifen (TAM) is a cell type-specific anti-estrogen and is applied to improve the survival of patients with estrogen receptor positive (ER +) breast cancer. However, long-term TAM use can induce serious drug resistance, leading to breast cancer recurrence and death in patients....

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Bibliographic Details
Main Authors: Hong-Yan Lin, Hong-Wei Han, Yin-Song Wang, De-Liu He, Wen-Xue Sun, Lu Feng, Zhong-Ling Wen, Min-Kai Yang, Gui-Hua Lu, Xiao-Ming Wang, Jin-Liang Qi, Yong-Hua Yang
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Chinese Medicine
Subjects:
Breast cancer
Shikonin
4-Hydroxytamoxifen
Drug combination
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13020-020-00305-1

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http://link.springer.com/article/10.1186/s13020-020-00305-1

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