Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection

Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection

The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling and HIV-1 LTR transcription. We hence hypothesized that Vpr might be a determinant of non-activated T-cell infection....

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Bibliographic Details
Main Authors: Kristin Höhne, Ramona Businger, Anouk van Nuffel, Sebastian Bolduan, Herwig Koppensteiner, Ann Baeyens, Jolien Vermeire, Eva Malatinkova, Bruno Verhasselt, Michael Schindler
Format: Article
Language:English
Published: The Royal Society 2016-01-01
Series:Open Biology
Subjects:
hiv-1
vpr
nfat
productive t-cell infection
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160046

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160046

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