Irradiation-Modulated Murine Brain Microenvironment Enhances GL261-Tumor Growth and Inhibits Anti-PD-L1 Immunotherapy

Irradiation-Modulated Murine Brain Microenvironment Enhances GL261-Tumor Growth and Inhibits Anti-PD-L1 Immunotherapy

PurposeClinical evidence suggests radiation induces changes in the brain microenvironment that affect subsequent response to treatment. This study investigates the effect of previous radiation, delivered six weeks prior to orthotopic tumor implantation, on subsequent tumor growth and therapeutic res...

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Bibliographic Details
Main Authors: Joel R. Garbow, Tanner M. Johanns, Xia Ge, John A. Engelbach, Liya Yuan, Sonika Dahiya, Christina I. Tsien, Feng Gao, Keith M. Rich, Joseph J. H. Ackerman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
MRI
radiation
tumor
microenvironment
immunotherapy
checkpoint inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.693146/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.693146/full

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