Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT

Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT

Abstract Background Metastasis is a major challenge in cervical cancer treatment. Previous studies have shown that the dual functional protein apurinic/apyrimidinic endonuclease 1 (APE1) promotes tumor metastasis and is overexpressed in cervical cancer. However, the biological role and mechanism of...

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Bibliographic Details
Main Authors: Qing Li, Zhi-Wei Zhou, Wei Duan, Cheng-Yuan Qian, Shu-Nan Wang, Meng-Sheng Deng, Dan Zi, Jian-Min Wang, Cheng-Yi Mao, Guanbin Song, Dong Wang, Kenneth D. Westover, Cheng-Xiong Xu
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
APE1
EMT
E-cadherin
ZEB1
Cervical cancer metastasis
Online Access:https://doi.org/10.1186/s13046-021-02006-5

Internet

https://doi.org/10.1186/s13046-021-02006-5

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