Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes)

Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes)

Vertebral endplate bone marrow lesions, visualized on magnetic resonance imaging (MRI) as Modic changes (MC), are associated with chronic low back pain (cLBP). Since guidelines recommend against routine spinal MRI for cLBP in primary care, MC may be underdiagnosed. Serum biomarkers for MC would allo...

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Bibliographic Details
Main Authors: Stefan Dudli, Alexander Ballatori, Anne-Christine Bay-Jensen, Zachary L. McCormick, Conor W. O’Neill, Sibel Demir-Deviren, Roland Krug, Irina Heggli, Astrid Juengel, Jaro Karppinen, Florian Brunner, Mazda Farshad, Oliver Distler, Jeffrey C. Lotz, Aaron J. Fields
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
Modic change
low back pain
biomarker
connective tissue
basement membrane
bone marrow
Online Access:https://www.mdpi.com/1422-0067/21/11/3791

Internet

https://www.mdpi.com/1422-0067/21/11/3791

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