Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair

Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair

Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhib...

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Bibliographic Details
Main Authors: Shuang Zhang, BS, Xin-Yi Yeap, MS, Matthew DeBerge, PhD, Nivedita K. Naresh, PhD, Kevin Wang, BS, Zhengxin Jiang, PhD, Jane E. Wilcox, MD, Steven M. White, MD, PhD, John P. Morrow, MD, Paul W. Burridge, PhD, Daniel Procissi, PhD, Evan A. Scott, PhD, William Frazier, PhD, Edward B. Thorp, PhD
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:JACC: Basic to Translational Science
Subjects:
phagocytosis
CD47
macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X17301298

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http://www.sciencedirect.com/science/article/pii/S2452302X17301298

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