Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients

Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients

Post-translational modification of small GTPases by farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP) has generated much attention due to their potential contribution to cancer, cardiovascular and neurodegenerative diseases. Prenylated proteins have been identified in numerous cell functions an...

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Bibliographic Details
Main Authors: Gunter P. Eckert, Gero P. Hooff, Dana M. Strandjord, Urule Igbavboa, Dietrich A. Volmer, Walter E. Müller, W. Gibson Wood
Format: Article
Language:English
Published: Elsevier 2009-08-01
Series:Neurobiology of Disease
Subjects:
Alzheimer disease
HMG-CoA reductase
Isoprenoids
Farnesylpyrophosphate
Geranylgeranylpyrophosphate
Prenylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001028

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http://www.sciencedirect.com/science/article/pii/S0969996109001028

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