Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines.

Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines.

G-quadruplexes are higher-order DNA structures formed from guanine-rich sequences, and have been identified as attractive anticancer drug targets. Elucidating the three-dimensional structure of G-quadruplex with 9-amino acridines and the specific interactions involved in binding selectivity are the...

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Bibliographic Details
Main Authors: Ruben Ferreira, Roberto Artali, Adam Benoit, Raimundo Gargallo, Ramon Eritja, David M Ferguson, Yuk Y Sham, Stefania Mazzini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3598906?pdf=render

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http://europepmc.org/articles/PMC3598906?pdf=render

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